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Nude mouse phenotype nk cells

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A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus , resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype main outward appearance of the mouse is a lack of body hair, which gives it the "nude" nickname. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no rejection response. These xenografts are commonly used in research to test new methods of imaging and treating tumors. The genetic basis of the nude mouse mutation is a disruption of the FOXN1 gene.
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Immunodeficient Mouse and Xenograft Host Comparisons

Nude mouse phenotype nk cells
Nude mouse phenotype nk cells
Nude mouse phenotype nk cells
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Immunodeficient Mouse and Xenograft Host Comparisons

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Practical NK cell phenotyping and variability in healthy adults

NK cells are lymphocytes of the innate immune system which are a first line of defense against infections and tumor cells, in bone marrow and peripheral organs like lung and spleen. The lung is an organ in contact with respiratory pathogens and the site of inflammatory disorders triggered by the respiratory environment. In contrast, spleen is a lymphatic organ connected to the blood system which regulates the systemic immune response. Here we compare NK cell maturation and expansion as well as expression of NK cell receptors in spleen and lung compartments. We show that spleen and lung NK cells differ in phenotypic and functional characteristics due to a difference of maturity and cellular microenvironment.
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JAX distributes a variety of immunodeficient strains that can be divided into four main categories:. A JAX Notes article thoroughly describes these offerings. Foxn1 encodes a transcription factor required for both hair follicle and thymic development. In its absence, mice are both hairless and athymic. Mice that carry either the Rag1 tm1Mom or Rag2 tm1.
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